|
Blood Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Blood pressure loci identified with a gene-centric array.
|
22100073 |
2011 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Hypertensive disease
|
0.700 |
Therapeutic
|
group |
RGD |
Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling.
|
29084084 |
2018 |
|
Hypertensive disease
|
0.700 |
Therapeutic
|
group |
RGD |
Radix
|
29285068 |
2017 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
Phosphorylated endothelial NOS Ser1177 via the PI3K/Akt pathway is depressed in the brain of stroke-prone spontaneously hypertensive rat.
|
20813549 |
2012 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.
|
18047920 |
2007 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
We hypothesize that alterations in nitric oxide synthase (NOS) activity or subcellular localization of NOS 3 protein may contribute to endothelial dysfunction in salt-dependent hypertension.
|
11882615 |
2002 |
|
Fetal Growth Retardation
|
0.690 |
Biomarker
|
phenotype |
RGD |
Intrauterine growth restriction and shallower implantation site in rats with maternal hyperinsulinemia are associated with altered NOS expression.
|
19709742 |
2009 |
|
Fetal Growth Retardation
|
0.690 |
Biomarker
|
phenotype |
RGD |
Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction.
|
29741931 |
2018 |
|
Pre-Eclampsia
|
0.680 |
Therapeutic
|
phenotype |
RGD |
Of note, apelin treatment significantly ameliorated the symptoms of preeclampsia, improved the impaired endothelial nitric oxide synthase/nitric oxide signaling and attenuated activation of oxidative stress in RUPP rats.
|
29250138 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
RGD |
Effect of AOB, a fermented-grain food supplement, on oxidative stress in type 2 diabetic rats.
|
18356581 |
2007 |
|
Diabetic Nephropathy
|
0.600 |
Therapeutic
|
disease |
RGD |
Cupuaçu extract reduces nitrosative stress and modulates inflammatory mediators in the kidneys of experimental diabetes.
|
29336891 |
2019 |
|
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats.
|
29351461 |
2018 |
|
Congestive heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats.
|
29351461 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Results showed reduced endothelial nitric oxide synthase (eNOS) protein expression in the MI group; increased iNOS activity in the HgCl<sub>2</sub>-MI group, although without enough magnitude to reverse the reduction in NO bioavailability; and increased phenylephrine response in the HgCl<sub>2</sub>-MI group due to an increase in ROS production, notably via xanthine oxidase (XO).
|
28980197 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
The results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression.
|
22012955 |
2012 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
In addition, ED was associated with decreased eNOS protein expression at both ages.
|
20807325 |
2010 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
|
17420087 |
2007 |
|
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
RGD |
TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats.
|
29260891 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
RGD |
Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome.
|
29127233 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Therapeutic
|
disease |
RGD |
Grape pomace reduced reperfusion arrhythmias in rats with a high-fat-fructose diet.
|
28967023 |
2017 |
|
Hyperlipidemia
|
0.530 |
Biomarker
|
disease |
RGD |
Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity.
|
17895290 |
2007 |
|
Diabetic Angiopathies
|
0.520 |
Therapeutic
|
disease |
RGD |
Early intervention with Didang decoction delays macrovascular lesions in diabetic rats through regulating AMP-activated protein kinase signaling pathway.
|
29329611 |
2017 |
|
Diabetic Angiopathies
|
0.520 |
Biomarker
|
disease |
RGD |
Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat.
|
19241604 |
2008 |
|
Cardiomegaly
|
0.510 |
Biomarker
|
phenotype |
RGD |
Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy.
|
17487232 |
2006 |